Nonhuman Primate Models and Developmental Neuronal Toxicity

Nonhuman Primate Models and Developmental Neuronal Toxicity

The existing data from research using rodent models have implicated some drugs as being toxic to the developing brain, even causing cognitive deficits in later life. However, there are no data providing evidence that the clinical use of these drugs is associated with signs of developmental neurotoxicity. This Editorial focuses on how use of the developing nonhuman primate, when combined with bi...

Nonhuman Primate Models for SARS

S evere acute respiratory syndrome (SARS) fi rst emerged in Guangdong Province, the People's Republic of China, in November 2002. The disease was characterised by a rapidly progressive atypical pneumonia [1]. In addition to other pathogens, a coronavirus not previously discovered was identifi ed in patients with SARS. Reproduction of a similar disease in cynomolgus macaques with this virus comp...

Nonhuman primate models of asthma

Asthma is a complex human disease that does not have an accurate counterpart in any common model organism. Most of our understanding of the immune mechanisms underlying asthma comes from studies in man and mouse. However, there are fundamental differences between the spontaneous disease in man and the experimentally induced counterparts in mice. We advocate more extensive use of nonhuman primat...

Assessment of Potential Neuronal Toxicity of Inhaled Anesthetics in the Developing Nonhuman Primate

Anesthetics have been used for years in pediatric patients without clinical evidence of adverse central nervous system (CNS) sequelae. In the current study, postnatal day (PND) 5–6 rhesus monkeys were exposed to nitrous oxide (N2O; 70%) alone, isoflurane (ISO; 1.0%) alone, or N2O plus ISO for 8 h. Six hours after completion of anesthetic administration, neuronal toxicity was examined using hist...

Nonhuman Primate Models of Human Ontogeny